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Chronic Obstructive Pulmonary Disease
COPD is a disease featuring chronic airflow obstruction and/or emphysema, which is characterised by cough, excessive sputum production and breathlessness. It is well documented in scientific literature that these clinical features lead to a decline in lung function. The EMMS eSpira™ system and invasive airway mechanics are both systems capable of giving a complete assessment of lung function with particular emphasis on measuring the loss of lung elastance and airflow obstruction. Whole body plethysmography is also a useful tool in assessing progressive changes occurring during a chronic animal study.
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The data above illustrates results obtained from a guinea pig pulmonary inflammatory model. Animals were exposed to a whole body aerosol of LPS. Twenty four hours later Forced Vital Capacity (FVC) was measured in anaesthetised subjects using the EMMS eSpira™ system. A statistically significant reduction in FVC was observed in animals exposed to LPS when compared with control animals. This model may be useful for COPD researchers as a mechanistic model of pulmonary neutrophil inflammation with associated lung dysfunction.